The evolution of knowledge, the serious one, necessarily passes through a time directed to the search for new molecules different from the existing ones, which are, however, equally effective!
Many “dreamed” of antimicrobial peptides because they represent a therapeutic alternative. In fact, at first the electrostatic and hydrophobic interactions determine an association between the peptide and the bacterial membrane’s surface and / or of the pathogen. Later the peptide molecules form holes on the cell surface, thus reducing the proton gradient, causing the leaking of molecules from the cytoplasm, inhibiting ATP production and slowing down other metabolic processes, until the microbial cell’s death. This is true, but there is a lot of confusion between natural peptides and peptides of synthesis. The firsts are already present in human and animal organisms, often in low quantities, easily deprived of their property and active only towards single pathogens. The peptides of synthesis have a number of advantages, including the possibility to be synthetized and modulated according to their meant purpose. This fundamental advantage allows overcoming all the limitations of the natural peptides! Since 2006 ICF, relying on science and not on fantasy, with the collaboration of the Departments of Clinical and Experimental Medicine and Medical and Veterinary Sciences of the University of Parma and the University Hospital of Parma, studied and developed an antimicrobial peptide of synthesis (AMP) and came to the creation and patenting of 100 sequences of peptides with targeted activity! Among those molecules, we focused so far on ‘AMP2041.
Per gentile concessione del Dipartimento di Scienze Mediche e Veterinarie, Università degli Studi di Parma
Multiple scientific evidences, including the efficacy and safety tests and articles published, prove that AMP2041:
• Has an antibacterial spectrum towards Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Salmonella), Gram-positive (S. aureus methicillin-susceptible and methicillin-resistant MRSA); Candida albicans and Malassezia pachydermatis;
• Has High solubility in water (> 95%);
• Has High stability guaranteed by the disulphide bridge;
• Has Salt-insensitivity that allows efficient use of the peptide under different environmental conditions;
• Has a synergic action with Chlorhexidine;
• Is not toxic to human and animal cells.
That is the reason why with AMP2041 “the future is now” … but a future based on science and not on fantasy…
